The Arizona Cardinals have lost four games in a row with a 31-27 loss to the Indianapolis Colts. The Cardinals, just like every game this season, had the lead in the fourth quarter and couldn’t close. The Colts came in with a 4-1-0 record, so they are on top of the standings and attempted to advance with a loss by their division foe Jacksonville Jaguars.

RELATED: CARDINALS DEFENSE COLLAPSES AGAIN

After beginning the season 2-0-0, Arizona now sits at 2-4-0. Somehow, this losing streak has to stop as the Cardinals sink further down the standings in the NFC West Division....

The Arizona Cardinals fell to the Indianapolis Colts on Sunday, despite the efforts of the offense lead by Jacoby Brissett.

It was once again a failure of the defense to get any fourth quarter stops that had the Cardinals taking that fourth straight loss, as the defense has not forced a single fourth quarter punt since week one.

Tough look for a defensive staff.

This week, everyone knew what needed to happen for the Arizona Cardinals to win the game, they had to slow down Jonathan Taylor. Notice, no one said stop Taylor, the Colts rushing attack is too good...

Another week, another fourth quarter loss for the Arizona Cardinals.

I guess the one difference is this time the offense was technically on the field with a chance to win and the defense had already screwed up.

Now the Arizona Cardinals host the Green Bay Packers, so I’m sure things are going to go well. So of course it makes a lot of sense that our friends at FanDuel Sportsbook have the Cardinals as 6.5-point home underdogs.

People have watched this team and know, despite the Packers coming back to earth after their first two games, they are back on...

We can talk all we want about the offense. They had their best outing of the season.

Yet for a sixth consecutive game, the defense has looked putrid in the fourth quarter and the Arizona Cardinals lose 31-27.

The Colts were not stopped once in the second half. The defense was again on the field the entire second half because they could not get off the field. Every time the Arizona Cardinals took the lead, the Colts would go down and either tie or take the lead.

The defense in the fourth quarter this year has been a straight up...

The Arizona Cardinals trail the Indianapolis Colts at the half and have had even more injuries pop up.

The biggest being Marvin Harrison Jr., who was targeted two times in the first half, and on the second one was knocked out of the game after the ball was thrown slightly behind him and he ended up banging his head on the turf.

We will see if he comes back in the second half, but he looked distressed after heading to the locker room without his helmet.

Jacoby Brissett is having an ineffecient, but effective game going 10/20 for 117 yards...

The Arizona Cardinals need a win.

The Arizona Cardinals are playing with a lot of backups, specifically in the backfield, and need them to play better than they have been. Or at least smarter.

For the Cardinals, this game will help them stay competitive, but a loss could be the beginning of the end of the 2025 NFL season.

No big deal, Jacoby Brissett has got this.

Week 6: Arizona Cardinals (2-3) at Indianapolis Colts (4-1)

Date: Sunday, October 12, 2025
Time: 10:00 a.m. AT
Location: Lucas Oil Stadium — Indianapolis, IN
National TV: Fox (Channel 10 locally)
**National...

Happy gameday one and all.

I am sure that there is a handful of you excited about today, I mean who doesn’t love a good journeyman quarterback story?

Yet, the Cardinals test resides in can they actually do anything to stop the Indianapolis Colts offense, that has been humming behind Jonathan Taylor.

Jess and I discuss the Arizona Cardinals upcoming game and what they need to do in order to stop the Colts. Then we discuss the matchups that matter, before making our picks for the game.

Enjoy.

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The Arizona Cardinals (2-3-0) have lost three straight games. Each one, they gave away. So, what do they need to do going forward?

They face a very good team in the Indianapolis Colts this weekend. Indy is currently 4-1-0 and tied for the lead in the AFC South Division. They have scored the second-most points in the league this season.

RELATED: CARDINALS COULD BE WITHOUT KYLER MURRAY

What will it take to defeat Indianapolis? How can the Cardinals stop this three-game losing streak and come away with a much-needed win?

Feed Trey McBride

The Cardinals are operating with...

Welcome to SB Nation Reacts, a survey of fans across the NFL. Throughout the year we ask questions of the most plugged-in Cardinals fans and fans across the country. Sign up here to participate in the weekly emailed surveys.

Not shocking, and quite frankly the fact that some fans still are onboard is impressive.

However, the Arizona Cardinals in the Jonathan Gannon era have bottomed out in terms of belief in the direction of the franchise, as they hit a new low.

Fans of the Cardinals are over how things are going, and need to see something way more from...

Happy Sunday one and all.

The Arizona Cardinals are trying to keep things close this year, and it is going to be a tough one as they head east to Indianapolis to take on a Colts team that is playing well in 2025.

So, can they do so with their entire starting backfield missing the game?

This is going to be an interesting game to watch.

Week 6: Arizona Cardinals (2-3) at Indianapolis Colts (4-1)

Date: Sunday, October 12, 2025
Time: 10:00 a.m. AT
Location: Lucas Oil Stadium — Indianapolis, IN
National TV: Fox (Channel 10 locally)
**National online...

The Arizona Cardinals made a couple of moves today ahead of their week six matchup with the Indianapolis Colts, the biggest one being elevating practice squad quarterback Kedon Slovis to the active roster, meaning we will be unlikely to see Kyler Murray one Sunday.

From the team:

The Arizona Cardinals Football Club today announced the following roster moves:

– Signed quarterback Kedon Slovis to the active roster from the practice squad

– Elevated defensive linemen Zach Carter and Anthony Goodlow to the active roster from the practice squad as standard elevations

– Placed...

It was fun.

Jess and I talk about the Arizona Cardinals loss to the Tennessee Titans and what happened.

In this one we take a look at another week of a complete collapse, some of the weirdest and bad plays we have ever seen, and then the worst ending imagineable.

Sit back, relax and let us be pissed for you.

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