Thursday Night Football Week 4: Seahawks at Cardinals Open Thread

The Seattle Seahawks are coming off a big win last week. Everything seemed to be firing on all cylinders during their 44-13 blowout win over the New Orleans Saints. However, I think the Arizona Cardinals defense is a bit more impressive. Being at home, I think the Cardinals could give Seattle some problems.

Kickoff is set for Thursday, September 25, 2025 at 6:15 p.m. Mile High time at State Farm Stadium in Glendale, Arizona and will air on Prime Video.

My Prediction

According to FanDuel, the Seahawks are slight road favorites here over Arizona at 1.5-points. I think the Cardinals win straight-up tonight as I am not a big believer in this Seahawks team right now. They’ve had a good start again some inferior opponents and while I’m not all that impressed with the Cardinals either, I’ll give them the nod being at home and under the prime time lights of Thursday Night Football.

Prediction: Cardinals 24, Seahawks 22

Open thread in the comments section below. Discuss the games action there!