ClutchPoints
The New Orleans Saints’ season has unraveled quickly. At 0-3, they’re staring down a brutal Week 4 matchup against the undefeated Buffalo Bills. The latter have looked every bit like one of the AFC’s premier teams. New Orleans needs any sort of spark to prove they can compete. At the same time, Buffalo has to avoid falling into the dreaded trap of overlooking this game. As Highmark Stadium braces for this lopsided contest, the stage is set for some bold predictions that could define whether this game is simply another Bills blowout or something more competitive than expected.
The Saints (0-3) head to Highmark Stadium in Orchard Park for a daunting Week 4 matchup against the Bills (3-0). The contrast between the two sides is stark. Buffalo has surged to an unbeaten start behind Josh Allen’s steady leadership and a defense that has suffocated opponents. Meanwhile, New Orleans arrives on the heels of an embarrassing Week 3 loss to Seattle. The Saints are still searching for offensive rhythm and stability at quarterback.
Pundits have little faith in a Saints upset, with Buffalo favored by double-digits. New Orleans hasn’t shown the talent, cohesion, or coaching edge to keep pace with one of the league’s most complete rosters. Still, the NFL is rarely predictable. The Saints could stay competitive if they generate turnovers, hit on a few timely big plays, or exploit Buffalo’s vulnerable run defense. The reality is clear, though. They face an uphill battle against one of the league’s hottest teams.
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Here we will look at and discuss some bold predictions for the game between the Saints and the Bills in Week 4 of the 2025 NFL season.
Josh Allen has a wealth of weapons at his disposal. However, tight end Dawson Knox remains one of his most trusted options in the red zone. Though he hasn’t scored yet this season, Knox has a history of stepping up when Buffalo needs him most. That’s particularly true in tight coverage situations near the goal line.
Against a Saints secondary that has struggled to contain tight ends, Knox has the perfect opportunity to break out. With Keon Coleman and Khalil Shakir often drawing double teams, Knox could become Allen’s go-to target inside the 20-yard line. We have Knox finding the end zone and leading all Bills pass-catchers in touchdowns for Week 4.
James Cook has been one of the brightest stars of Buffalo’s unbeaten start. Through three games, he’s racked up 284 yards and four touchdowns on the ground. He has also averaged over five yards per carry. He’s also been a reliable receiving option. That makes him a dual-threat nightmare for opposing defenses.
The Saints, who have been vulnerable against the run, could be in for a long afternoon. Cook has a chance to tie a franchise record by scoring...
