NFL Week 11 Opening Odds: Buccaneers at Bills

NFL Week 11 Opening Odds: Buccaneers at Bills
Bucs Nation Bucs Nation

The Tampa Bay Buccaneers have a 6-3 record after coming off a post bye week loss to the New England Patriots, signaling danger as the Bucs a crucial stretch of games. Tampa Bay has been able to overcome injuries for the most part and maintain a winning record, but next week’s matchup against the Buffalo Bills could prove to be another tough task.

How do the oddsmakers feel about this matchup for Tampa Bay? Per FanDuel, Tampa Bay is a 5.5-point underdog for Week 11 of the 2025 regular season.

Point spread: Bucs +5.5
Point total: 50.5
Moneyline: Bucs +220, Bills -270

Buffalo will look to redeem themselves at home after also dropping to 6-3 following their Week 10 loss to the Miami Dolphins. The Bills will still be riding the arm of quarterback Josh Allen as they look to get back on the winning side against a Bucs defense that gave up big plays against the Patriots that all went for touchdowns.

Next week’s game between the Bucs and Bills is scheduled for next Sunday with kickoff set for 1:00 PM ET.