NFL Week 10 Predictions: Picks for Every Game on NFL Schedule this Week

NFL Week 10 Predictions: Picks for Every Game on NFL Schedule this Week
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Chaos erupted in Week 9 of the 2025 NFL season. We saw big favorites like the Green Bay Packers, Indianapolis Colts and Detroit Lions all go down. Meanwhile, the Buffalo Bills took down the Kansas City Chiefs and the Chicago Bears survived a huge scare from the Cincinnati Bengals.

It’s a reminder that anything can happen on any given Sunday and the NFL schedule this week could be no different. With that in mind, let’s dive into our NFL Week 10 predictions.

Related: NFL Week 10 Power Rankings, see Risers an Fallers after Chaotic Week 9

Denver Broncos 27, Las Vegas Raiders 17

The good news for the Las Vegas Raiders in this Thursday Night Football matchup versus the Denver Broncos is that Brock Bowers is healthy. It’s an enticing matchup for the All-Pro, as one of the few vulnerabilities on this Broncos defense is its pass coverage versus tight ends (482 receiving yards and 13.0 yards per reception allowed). The good fortune ends there for Las Vegas. Denver comes into Week 10 with a league-high 40 sacks and the Raiders offensive line can’t hold up in pass protection. On top of that, Las Vegas has allowed 122.3 rushing yards per game in its last six contests. The Broncos should win this one comfortably.

Indianapolis Colts 28, Atlanta Falcons 20

The Atlanta Falcons defense is going to try to heat up Daniel Jones, as evidenced by the second-highest blitz rate (33.9 percent) in the NFL. However, Jones has carved up the blitz this season and the Indianapolis Colts offensive line can hold up well in pass protection. That’s not to mention the fact that Jonathan Taylor is facing a Falcons run defense that has allowed 141.2 rush ypg and 4.6 yards per carry in the last five games. Bijan Robinson’s big-play ability gives Atlanta a chance against Indianapolis, but the Colts are the better team and well equipped to handle what the Falcons throw at them.

Chicago Bears 31, New York Giants 24

This could’ve been one of the most entertaining games on the NFL schedule this week if not for the season-ending injuries to Cam Skattebo and Malik Nabers. It’s because of those absences that Jaxson Dart won’t have the weapons on this New York Giants offense to exploit a Chicago Bears defense that has allowed 20 passing touchdowns and a 5.1 yards-per-carry average to opponents this season. Instead, Chicago gets to have the big advantage as New York has allowed 150 rush ypg and 5.5 yards per carry this season, all the while allowing 231.1 passing yards and 1.7 passing touchdowns per game to opposing quarterbacks.

Buffalo Bills 38, Miami Dolphins 20

The Thursday Night Football matchup between the Miami Dolphins and Buffalo Bills a few weeks ago was closer than expected. We don’t anticipate that being the case in this Week 10 rematch. Miami waved its white flag on the season with the Jaelan Phillips trade, and that will make a bottom-five defense...