NFL Week 1 Predictions: Projecting Every Game on Week 1 Schedule

NFL Week 1 Predictions: Projecting Every Game on Week 1 Schedule
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A new season for the National Football League has finally arrived, with the preseason over and Week 1 delivering the caliber of action that fans have been waiting for. It’s a bit of a unique NFL schedule for Week 1 with games on Thursday, Friday, Saturday and Sunday to keep everyone happy all weekend long.

Let’s dive into our NFL Week 1 predictions, forecasting the outcome of every game in the first week of the 2025 NFL regular season.

NFL Kickoff Game: Philadelphia Eagles 31, Dallas Cowboys 17

Even without the Micah Parsons trade, the Dallas Cowboys were likely going to lose to the Philadelphia Eagles to kick off the 2025 NFL season. It now feels like a virtual certainty. With this defense now missing its All-Pro edge rusher, one of the few things it had to attack the Eagles’ offense, it could get ugly. Philadelphia was already going to be able to run the football on the Cowboys’ defense. Now, Jalen Hurts will have a clean pocket to operate from, and that’ll help Philadelphia cruise to a Week 1 win.

Related: Game-by-Game Philadelphia Eagles Predictions 2025

NFL Brazil Game: Kansas City Chiefs 23, Los Angeles Chargers 16

The Kansas City Chiefs offense takes a hit in this one with Rashee Rice suspended and two inexperienced starters on the left side of the offensive line. However, the Los Angeles Chargers don’t have Rashawn Slater, and the talent gap between these two rosters is fairly significant. In what’s effectively a neutral-site game in Brazil, mistake-free football from Kansas City leads them to win by a touchdown.

Related: Game-by-Game Chiefs Predictions; Game-by-Game Chargers Predictions

Tampa Bay Buccaneers 28, Atlanta Falcons 24

Both the Atlanta Falcons (Kaleb McGary) and the Tampa Bay Buccaneers (Tristan Wirfs) will be without their blindside protectors in Week 1. Coincidentally, neither team necessarily has the pass rush to take full advantage of it. However, we do trust both the Buccaneers’ defensive line and quarterback Baker Mayfield more to capitalize on the opportunities they’re given to make plays. It’ll be a close battle, but Tampa Bay comes out of it with a 1-0 record and a key win over a divisional opponent early in the season.

Related: Week 1 Fantasy Rankings, Best Fantasy QB, RB, WR and TEs This Week

Cincinnati Bengals 24, Cleveland Browns 13

The one thing the Cleveland Browns have going for them in this season-opening matchup is defensive linemen Myles Garrett and Mason Graham against the Cincinnati Bengals‘ offensive line. Those two disruptors in the trenches and cornerback Denzel Ward should allow Cleveland to hold Joe Burrow and Co. under 28 points. However, a lifeless Browns’ offense will ensure that Burrow, Ja’Marr Chase, and Chase Brown don’t have to do too much to pull out the win.

Related: Game-by-Game Cincinnati Bengals Predictions 2025

Miami Dolphins 24, Indianapolis Colts 17

While we don’t have a ton of confidence in the Miami Dolphins being a playoff-caliber team this year, they have everything...