ClutchPoints
Week 4 ended with a whimper with two dog Monday night games. Will Week 5 be a little stronger all the way through? We’ll see starting Thursday night, with another NFC West showdown, this time between the San Francisco 49ers and Los Angeles Rams. So, let’s dig into the ClutchPoints 2025 NFL Week 5 picks, predictions, and odds column.
Last weekend delivered high highs and low lows. On the plus side, there was a fun first-ever game in Dublin, Jaxson Dart’s winning debut, another blocked field goal that decided a game, and a ton of fun (if ultimately unsatisfying) 40-40 Sunday night tie.
Unfortunately, though, there were also several crushing injuries to the likes of Malik Nabers, Tyreek Hill, Joe Alt, and Lamar Jackson. Let’s hope that the NFL Week 5 calendar can deliver more of the former and a whole lot less of the latter.
With the first round of byes this week, we say goodbye to the Atlanta Falcons, Chicago Bears, Green Bay Packers, and Pittsburgh Steelers. Hopefully you enjoyed Sunday’s full complement of games, because we don’t get another 16-game weekend until Thanksgiving’s Week 13.
Here in Week 5, we’ll get a Thursday night game, a 9:30 a.m. ET matchup from London, England, six 1:00 p.m. ET games, four late window tilts, a Sunday night affair, and one Monday night showdowns.
Week 4 was a tough one against the spread with some wild finishes and backdoor covers. While we went 10-6 straight up, we were only 6-10 ATS. That brings us to 42-22 straight up and 32-32 ATS on the season, so at least we’re still breaking even on that side.
Previous weeks: Week 1 | Week 2 | Week 3 | Week 4
So, let’s get right into the NFL Week 5 picks, predictions, and odds.
Courtesy of DraftKings, here are the NFL odds.
The Rams and 49ers are in a virtual three-way tie with the Seahawks for the top of the NFL West, making this Thursday night game an important one. But neither team is coming in great, as LA should have lost last week (if not for Adonai Mitchell) while San Francisco did.
This game has trended Rams, with the line jumping from -6 to -8.5 over the course of the week. And, while the 49ers continue to be incredibly banged-up, this is still a divisional game, which are often closer than meets the eye, especially between Kyle Shanahan and Sean McVay. We’ll still take the Rams, but not by more than a touchdown.
Pick: Rams 23-20
Back to jolly old London, the Browns travel overseas to face a Vikings team that has been in the British Isles since taking on the Steelers in Dublin last week. While that does seem like an advantage, to be on local time for more than a week, the Vikings are also starting Carson Wentz again, which is a major disadvantage.
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