ClutchPoints
There have been 256 NFL games played this regular season, and after Week 18, we get to 272 and move on to the postseason. With the interconnectivity of the final slate of games, the league will play all 16 this week in a two-day window on Saturday and Sunday to try to keep as many contests as meaningful as possible. So, let’s dive right into the ClutchPoints 2025 NFL Week 18 picks, predictions, and odds column.
The last week of the NFL regular season is a “be careful out there, friends” situation. While all these games have 2026 NFL Draft implications and some will move playoff seeding as well, anything can happen in the final games.
Coaches may rest their players from the start, or if they are scoreboard watching, pull star players if another game is going a certain way. Teams that are out of the playoffs may have one foot in their plane to Cancun, while others may use this as an opportunity to put one more high-intensity effort on tape for their next coach or team.
Overall, spreads are big, and outcomes are even more variable than usual, so proceed with caution. If you are a volume bettor who likes to spread a little around on a lot of games, this may be a week to change things up and be a little more selective on games you feel good about. Don’t worry, next week you can get back to action on every game!
Thursday and Monday Night Football are over now that everything is on the line (for a few teams) in Week 18. So, on this slate, we get all the NFL games condensed in a two-day window. On Saturday, we have 4:30 pm and 8:00 pm ET kicks, while on Sunday, we get six 1:00 p.m. ET games, a massive seven late window tilts, and a Sunday night affair.
After a solid Week 16, we came back to earth on Week 17, going 8-8 straight up and 6-9-1 against the spread. This brings us to 153-103 when just picking winners and helps us improve to 115-135-6 ATS on the season.
Previous weeks: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9 | Week 10 | Week 11 | Week 12 | Week 13| Week 14| Week 15 | Week 16 | Week 17
So, with that, let’s get right into the NFL Week 18 picks, predictions, and odds.
Courtesy of DraftKings, here are the NFL odds.
The two teams in this winner-take-all game got here in wildly different ways. The Panthers exceeded expectations and grinded out wins to get to the top of the NFC South, while the Buccaneers fell off a cliff in the second half, losing seven of their last eight games. Either way, they ended up here, and one of these teams will get into the...
