ClutchPoints
The NFL likes to make it hard to get all your holiday shopping done in time by putting two games on Saturday in the week ahead of Christmas. That said, having a game on in the background of the holiday party you have to attend this weekend will help make your friends and family more tolerable. So, ahead of the week’s massive Thursday NFC West matchup between the Seattle Seahawks and Los Angeles Rams, let’s dive into the ClutchPoints 2025 NFL Week 16 picks, predictions, and odds column.
With 13 teams officially eliminated and just five teams on the outside looking in, the playoff picture is starting to take shape. So, while that means there will be more than a few meaningless games this weekend, it also means there are some pseudo-playoff games on the schedule this week, starting with the Thursday banger.
In fact, half the games this week are between two teams, both in or still alive in the playoff race. This will make for some incredibly dramatic and fun football!
As we enter the home stretch with 16 games per weekend, this week we get a Thursday night matchup, two Saturday showdowns kicking at 5:00 pm and 8:20 pm ET, seven 1:00 p.m. ET games, four late-window tilts, a Sunday night affair, and a Monday nighter.
We fell back to earth a bit, especially versus the number, in Week 15 was as we went 9-7 straight up and 6-10 against the spread. Overall, we are now 132-92 straight up, and 99-121-4 ATS on the season.
Previous weeks: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9 | Week 10 | Week 11 | Week 12 | Week 13| Week 14| Week 15
So, with that, let’s get right into the NFL Week 16 picks, predictions, and odds.
Courtesy of DraftKings, here are the NFL odds.
Our narrative brain is screaming, “Stay away from Sam Darnold in a big game!” right now. However, the analytical side is saying that the Seahawks are home on a Thursday night, while the Rams are without their most accomplished wide receiver, and their best pass-catcher spent the morning of the game crafting a PR apology.
This is a bet on the Seahawks as a team, believing that on a Thursday night at home, they have enough running and defense to get past a division rival. If Darnold can shake off the big game choker label in the process, all the better.
Pick: Seahawks 24-21
The Commanders stepped up to the plate last week and took down the Giants despite several signs pointing toward the G Men getting the win. This week, they take on another division foe. Do they have enough left in the tank to at least give the Eagles a hard time in a divisional matchup?
It may...
