NFL picks, predictions, odds for Week 15: The final month begins

NFL picks, predictions, odds for Week 15: The final month begins
ClutchPoints ClutchPoints

Exactly one month from today (Thursday, Dec. 11, 2025), we will be smack in the middle of Wild Card Weekend. Until then, there is a lot to still be decided, as just nine teams are mathematically eliminated from playoff contention heading into Week 15. So, as we kick off the last month of the regular season with the Atlanta Falcons vs. Tampa Bay Buccaneers on Thursday night, let’s dive into the ClutchPoints 2025 NFL Week 15 picks, predictions, and odds column.

On the flipside of about a quarter of the league being officially out of the playoffs, not a single team is 100% guaranteed to be in the postseason at this point. That said, the Denver Broncos, New England Patriots, Los Angeles Rams, Jacksonville Jaguars, Seattle Seahawks, and Buffalo Bills all come into Week 15 with a 96% chance or higher to make it, according to NFL.com.

That means there are a lot of big games on this week’s schedule, and by this time next week, we’ll have a much clearer picture of what the playoffs will look like.

We finally say goodbye to byes, as we welcome back the Carolina Panthers, New England Patriots, New York Giants, and San Francisco 49ers. Now, all 32 teams will play football every weekend for the final stretch of the season… that is, if you consider what teams like the Las Vegas Raiders, Cleveland Browns, and Tennessee Titans do, “playing football.”

Here in Week 15, we get the last traditional weekend schedule before the Saturday slate kicks in. That means a Thursday night matchup, eight 1:00 p.m. ET games, a robust five 4:25 pm ET tilts, a Sunday night affair, and a Monday night showdown.

Week 14 may have been a turning point for us here, as we went 8-6 both straight up and against the spread. As for picking winners, it wasn’t our best week, but gaining two games back ATS starts our climb back up Mount .500. Overall, we are now 123-85 straight up, and 93-111-4 ATS on the season.

Previous weeks: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9 | Week 10 | Week 11 | Week 12 | Week 13| Week 14

So, with that, let’s get right into the NFL Week 15 picks, predictions, and odds.

Courtesy of DraftKings, here are the NFL odds.

Atlanta Falcons at Tampa Bay Buccaneers (-4.5)

Despite the highest of hopes for these two teams at the beginning of the year, the truth is, the Panthers are probably the best team in the NFC North. Still, we’re left with the Disappointment Bowl in Thursday night, so we have to make a pick.

The Thursday night games have been all over the place, just like these two teams. So, it wouldn’t be a shock if this game went in almost any direction. We’ll take the Buccaneers to win here and, while we’d usually take a...