ClutchPoints
Thanksgiving marks the start of the home stretch of the NFL season, which means we’re only a week away from the start of the proverbial Witching Hour, as Scott Hansen would call it. And this slate starts strong, with a Buffalo Bills vs. Houston Texans matchup to kick things off. Ahead of that, here is the ClutchPoints 2025 NFL Week 12 picks, predictions, and odds column.
On paper, Week 12 could be a bit of a snoozefest. There are three games with double-digit spreads on the calendar and only two with lines that are less than a field goal. Plus, we’ll have quarterback luminaries like Tyrod Taylor, Marcus Mariota, Davis Mills, Jameis Winston, Jacoby Brissett, Shedeur Sanders, and likely Mason Rudolph starting.
Still, there are some solid division games (Minnesota Vikings vs. Green Bay Packers and Dallas Cowboys vs. Philadelphia Eagles), and intriguing conference matchups like the Kansas City Chiefs vs. the Indianapolis Colts and Tampa Bay Buccaneers vs. the Los Angeles Rams. Plus, at this point in the season, teams can still jump up and surprise us on a given Sunday.
This week, we welcome back the Indianapolis Colts and New Orleans Saints, while we say “see you soon” to the Denver Broncos, Los Angeles Chargers, Miami Dolphins, and Washington Commanders.
Here in Week 12, with the international games done for the season, we get a Thursday night game, seven 1:00 p.m. ET games, four late-window tilts, a Sunday night affair, and a Monday night showdown.
After a winning Week 10, we came back down to earth in Week 11. We were 7-8 straight up, which was our first straight-up losing week of the season. At 6-8-1 against the spread, we were a little better, but not by much. Overall, this brings us to 94-70 straight up and 76-86-2 ATS on the season.
Previous weeks: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9 | Week 10 | Week 11
So, let’s get right into the NFL Week 12 picks, predictions, and odds.
Courtesy of DraftKings, here are the NFL odds.
The Bills rebounded last week yet again and looked like a true contender after being embarrassed by the Dolphins the week before. So, in Week 11, when Buffalo faces a Houston squad led by Davis Mills, will they step up to the challenge (or lack thereof)?
Bills Mafia should beware of division games, matchups with balanced teams that run and take away the run, or teams that are incredibly well-coached. The Texans don’t check any of those boxes, so we’ll take the Bills all the way.
Pick: Bills 35-13
This is a must-win game for the Chiefs as they fight for their playoff lives, whereas the Colts are in much better shape coming off a bye. Between the home-field advantage and the desperation narrative, there likely...
