ClutchPoints
Put the kids to bed (it’s finally a school night again), get off that political thread on social media, and fire up your sports betting app of choice, because the NFL is back, baby! When the 2025 season kicks off with a banger between the Dallas Cowboys and Philadelphia Eagles, all is finally right in the world again because it’s football season. So, without further ado, let’s jump right into the ClutchPoints 2025 NFL Week 1 picks, predictions, and odds column.
Welcome to Year 4 of the ClutchPointsNFL picks, predictions, and odds column. If you are new, or just to refresh your memory, we do this every week picking the winners straight up and against the spread all the way through the Super Bowl.
That means we once again find ourselves 285 games from crowning a Super Bowl champion, and each week we will try to combine our knowledge, data, and studying trends to identify which teams will take home the W each week, or at least look good enough in an L to cover the spread.
For the NFL Week 1 slate, we’ll pick the Thursday nighter, the Friday special edition contest, eight early-window Sunday games, four late-window tilts, the Sunday night slugfest, and the standalone Monday night affair.
Last season, we were 177-108 (62.1%) straight up and 140-140-5 (50%) ATS on the season after a tough last two rounds of the playoffs. In 2023, we went 184-101 (64.5%) straight-up and 150-124-11 (54.7%) with the points.
So, with all that on the table, let’s get right into the NFL Week 1 picks, predictions, and odds.
Courtesy of DraftKings, here are the NFL odds.
What a matchup between the Jalen Hurts-led Eagles offense and the Cowboys defense, headlined by the newly re-signed Micah Par- (checks notes) Daron Bland!
Yes, teams often start slow after a Super Bowl, but the Eagles bring back almost everyone from the championship team and should be in it until the end again. We’ll take the Eagles here, but not by over a touchdown in a divisional game.
Pick: Eagles 24-20
The Chiefs showed last season that they can turn it on when they need to—be it late in games or in the playoffs—and still get the job done. While a Super Bowl butt-kicking may have them come out a little more fired up, the AFC West is catching up with the dynastic franchise.
In this matchup, the Chargers have everything to prove, and in Year 2 under Jim Harbaugh, look for LA to be tougher and more physical than they’ve been in years, which spells trouble for KC.
Pick: Chargers 28-27
In the other NFL Week 1 NFC East battle, a team that was excellent last season takes on another with lots of question marks. Still, the Commanders aren’t a sure thing yet heading into Year 2 with Jayden Daniels, and...
