NFL picks, predictions, odds for the NFL Wild Card playoffs: The beginning of the end

NFL picks, predictions, odds for the NFL Wild Card playoffs: The beginning of the end
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Almost four months to the day after the Baltimore Ravens choked up a lead to the Buffalo Bills to close Week 1 of the 2025 NFL season, the Ravens did the exact same thing against the Pittsburgh Steelers to pull the curtain down on Week 18. Now, it’s on to the postseason, where we will crown a Super Bowl champion on February 8. So, let’s dive right into the ClutchPoints 2025 NFL Wild Card playoffs picks, predictions, and odds column.

Now that the 272-game grind is over, we come to the playoffs with the 16 best teams competing for the Lombardi Trophy. No more pretenders, no more middling football teams (well, we still have the Panthers, but I digress), and no more New York Jets.

While the Denver Broncos and Seattle Seahawks get to sit at home, rest up, and fight off rust for a week, this NFL Wild Card Weekend gives us six must-see matchups that should provide some incredible football games. And one of the ways we can be sure of this is that we’ve seen several of these matchups already this season.

The Chicago Bears and Green Bay Packers split their season series, while the Carolina Panthers upset the Los Angeles Rams in Week 13.

However, we also have the Buffalo Bills at Jacksonville Jaguars, San Francisco 49ers at Philadelphia Eagles, Los Angeles Chargers at New England Patriots, and Houston Texans at Pittsburgh Steelers, which are all first-time matchups this season that should produce scintillating results.

The NFL Wild Card playoffs schedule brings us two Saturday games at 4:30 pm and 8:00 pm ET, three Sunday games with 1:00 pm, 4:30 pm, and 8:00 pm ET kicks, and a Monday night showdown in the usual 8:15 pm ET timeslot.

We did pretty well overall in the topsy-turvy Week 18 world, going 12-4 and 10-6 against the spread. That winning week puts us up at 165-107 when just picking winners and helps us improve to 125-141-6 ATS on the season.

Previous weeks: Week 1 | Week 2 | Week 3 | Week 4 | Week 5 | Week 6 | Week 7 | Week 8 | Week 9 | Week 10 | Week 11 | Week 12 | Week 13| Week 14| Week 15 | Week 16 | Week 17| Week 18

So, with that, let’s get right into the NFL Wild Card playoffs picks, predictions, and odds.

Courtesy of DraftKings, here are the NFL odds.

Los Angeles Rams (-10.5) at Carolina Panthers

The last time the Rams and Panthers squared off, it produced one of the most shocking results of the 2025 NFL season. Matthew Stafford threw not only his first interception in 318 attempts, but he also followed that up by throwing a pick-six two throws later.

That Michael Jackson touchdown put the Panthers up 14-7, and they would go on to win 31-28. It was a game that would ultimately help cost the Rams the No. 1 seed in the NFC and help the...