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There are tough decisions across the board for the fantasy football playoffs, including the quarterback position. And there will be tough calls to make for defense. Looking deeper, here is the start ‘em, sit ‘em advice for Week 16 of the 2025 NFL season.
It’s getting to the time of year when you may have to trust a defense that hasn’t proved trustworthy. But when the matchup is right, even bad defenses can make big plays.
Included in the mix are the Buffalo Bills. They’ve been all over the board this season, but delivered a No. 2 finish in Week 8 and repeated that in Week 13. And here’s the reason why they’re back in play.
The Bills can pick the football. They’ve proven that with 11 interceptions on the season. That ranks No. 13 in the NFL. Not great, but serviceable.
But they rank No. 9 overall, thanks to seven fumble recoveries. And now they get a shaky quarterback in Shedeur Sanders. The rookie threw three interceptions in his most recent game and went down via sack five times.
This is a super opportunity for the Bills to put together a top-five fantasy week, according to NBC Sports.
“The Bills haven’t been a great fantasy defense,” Gary Davenport wrote. “The team ranks outside the top-20 in fantasy points for the season, in part because Buffalo has struggled much of the season to stop the run. But this week brings the matchup that fixes all that ails a fantasy defense — the cacophony of crap that is the Cleveland Browns. Last week, the Browns managed to run for all of 50 yards. Shedeur Sanders threw three interceptions. And the Browns had less than 200 yards of offense and scored three points.”
Feast, Bills, feast!
Still, the Bills need to be better against the run, something head coach Sean McDermott certainly understands, according to atozsports.com.
“We were giving up some runs, and then because of that, they were a two-dimensional offense and keeping us off balance a little bit there,” McDermott said. “Run defense usually starts with gap integrity, so we’ll look at it and address it. We’ve got to be better, that’s for sure.”
And McDermott said not only the defense but the whole team needs to start faster.
“That’s something we have to work on, something we have to, you know, get into a rhythm sooner,” McDermott said. “But there’s also an ability to adjust during a game. Anybody can come up with a game plan, but it’s also what happens when they take certain things away, are you able to pivot and adjust, and I think that’s a sign of a great staff.”
Count on the Bills for at least four sacks and two turnovers.
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