NFL Fantasy Football Week 12 2025 Start ‘Em Sit ‘Em: Running Back

Week 11 of the 2025 NFL season featured some surprising production from a few running backs. Sean Tucker’s shocking three-touchdown game has to top the list. Fantasy managers will be expecting running backs to have another strong outing in Week 12.

There are a few tasty matchup this week that could result in some huge fantasy performances. But there are also a few name brand players who you’ll want to stay away from.

Below we will explore which running backs you should start and sit during Week 12 of the 2025 fantasy football season.

Start ‘Em

Alvin Kamara, NO (vs. ATL)

Kamara has certainly taken a step back as a fantasy asset in 2025. But he is still capable of putting up RB1 production in the right situation. And it may finally be time for Kamara to shine in Week 12.

The veteran running back was very involved in New Orleans’ last game against Carolina. He had 22 carries for 83 rushing yards, plus three receptions for 32 receiving yards.

Atlanta should be an ideal matchup for New Orleans. The Falcons have allowed 138.5 rushing yards per game so far this season. That is in the bottom five among all NFL teams, putting them alongside teams like the Dolphins, Giants, and Bengals.

This could set the stage for Kamara having his best game of the season. Rookie Devin Neal will likely be involved too, but Kamara figures to get the bulk of the work.

Beyond a favorable matchup, the game script could really go in New Orleans’ favor. The Falcons could be reeling after injuries to both Michael Penix Jr. and Drake London. If the Saints can stop Bijan Robinson, then the Falcons’ offense might crumble.

Fantasy managers should pray for a lopsided game that gets out of hand quickly. If that happens, Kamara can gobble up extra carries during garbage time.

Start Kamara with confidence this week.

Woody Marks, HOU (vs. BUF)

Marks appears to have taken over Houston’s backfield, overtaking veteran Nick Chubb.

The rookie running back had 18 carries for 44 yards against the Titans in Week 11. The efficiency wasn’t there, but he clearly had the leading role over Chubb (three carries for 17 yards).

Marks should be in line for another healthy workload against the Bills on Thursday Night Football.

Efficiency will be the name of the game for Marks. All he needs is one touchdown, or a couple of long runs, to become fantasy relevant. And the points still count even if he has plenty of short runs on top of that.

What really has me excited about Woody Marks is the possibility that he gets involved in the receiving game.

Emanuel Wilson, GB (vs. MIN)

This is one of the trickiest choices of the week.

Josh Jacobs suffered a knee injury in Week 11 and did not return, opening the door for Emanuel Wilson to take over.

Wilson logged 11 carries for 40 yards and a touchdown in relief...