Mile High Report
Remember when the Indianapolis Colts were the hottest team in the NFL? Feels like ages ago, because they have completely collapsed since that moment. Meanwhile, the San Francisco 49ers weathered a slew of injuries and quietly kept finding ways to win. They are now getting healthy and are catching fire at the perfect moment late in the season.
Kickoff is set for Monday, December 22, 2025 at 6:15 p.m. Mile High time at Lucas Oil Stadium in Indianapolis, Indiana and will air on ESPN/ABC.
According to FanDuel, the 49ers are 5.5-point favorites over the Colts. The biggest unknown is how will Philip Rivers fare in his second game back? Honestly, I think he’ll be due for a trainwreck game at some point. Just a hunch. Brock Purdy has been playing really well and this is a game where I think the 49ers could dominate from start to finish. The NFC West is clearly the best division in football and the 49ers have a chance to get the top seed despite everyone talking about the Seattle Seahawks and Los Angeles Rams.
Prediction: 49ers 34, Colts 16.
