Mile High Report
Most would have assumed an easy win for the San Francisco 49ers in this game about two months ago, but the Carolina Panthers have come on strong after a horrible start to the season. They were 1-3 then, but have won five of their last seven games and are playing some good football. Meanwhile, the 49ers can’t seem to figure things out and are .500 over their last eight games.
Kickoff is set for Monday, November 24, 2025 at 6:15 p.m. Mile High time at Levi’s Stadium in Santa Clara, California and will air on ESPN/ABC.
According to FanDuel, the 49ers are huge 7.5-point favorites over the Panthers in this game. While I think they will find a way to win, I do not think they are touchdown favorites in any game right now with the amount of injuries they’ve had to deal with. The Panthers defense is playing very well, so I expect a closer type game. I do think the 49ers win, though.
Prediction: 49ers 24, Panthers 19.
