Hogs Haven
We’ve got one game left for Week 16 of the 2025/’26 NFL season. This week’s Monday Night Football features the San Francisco 49ers visiting the Indianapolis Colts. The 49ers are 10-4, but in third place in a hyper-competitive NFC West. They have three games to move up the rankings. Phillip Rivers came out of retirement last week, and didn’t get killed on the field! He’s up to start again today, and this week might not go as smoothly.
Who: San Francisco 49ers (10-4) at Indianapolis Colts (8-6)
Where: Lucas Oil Stadium | Indianapolis, IN
When: December 22, 2025, 8:15 p.m.
TV: ABC/ESPN
Joe Buck (play-by-play)
Troy Aikman (analyst)
Lisa Salters (sideline)
Sirius XM NFL
San Francisco: XM/SXM 226, Internet 819
Indianapolis: XM/SXM 225, Internet 826
National: 88
Español: 227, Internet 832
FanDuel Sportsbook odds: 49ers -5.5, 46.5 O/U
San Francisco: -270
Indianapolis: +220
Prediction: 49ers 27 – Colts 17
SB Nation Blogs: Niners Nation | Stampede Blue
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