Full San Francisco 49ers game-by-game predictions after 2025 NFL schedule release

Full San Francisco 49ers game-by-game predictions after 2025 NFL schedule release
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The San Francisco 49ers will look to bounce back from an awful 2024 season, where they went 6-11. We will look at every game on their 2025 schedule and predict which games the 49ers will win and which they will lose. The Niners look very different, as they have lost a few players and have many rookies on the defensive side of the ball. But they also have an easy schedule, at least on paper, and look poised to rebound from the sad showing in 2024.

Week 1: @ Seattle Seahawks

The Niners start the season against an old foe that will have new faces abound, as the Hawks signed Cooper Kupp to be their newest wide receiver after losing DK Metcalf, and also have a new quarterback as Sam Darnold has signed with the team. It won’t be enough as the 49ers beat their divisional rivals to start the 2025 season.

WIN

Week 2: @ New Orleans Saints

This should be a very winnable game. Derek Carr has retired, leaving the Saints with Tyler Shough, Spencer Rattler, and Jake Haerner as their only options. According to FanDuel, the Saints currently have the worst odds to win the Super Bowl. The Niners will have more than enough to beat the Saints in New Orleans.

WIN

Week 3: vs. Arizona Cardinals

The Cardinals swept the 49ers last season, but it could have been a split. Significantly, the 49ers led 23-10 at halftime against the Cardinals in the game in Santa Clara, but fell apart, allowing 14 unanswered points in a 24-23 loss to the Cardinals. I think the Niners lay an egg here, losing their home opener after blowing another fourth-quarter lead.

LOSS

Week 4: vs. Jacksonville Jaguars

The 49ers are 2-0 in their history against the Jaguars at home, and always seem to bring their best game. I can see the 49ers bouncing back, with Brock Purdy firing two touchdowns to Juwan Jennings to lead them to a blowout win over the Jags at Levi.

WIN

Week 5: @ Los Angeles Rams (Thursday Night Football)

The Rams swept the 49ers last season, and this will be a tough turnaround with Thursday Night Football on the road in LA. I can see Puka Nicua scoring a go-ahead touchdown to take down the Niners late in Los Angeles.

LOSS

Week 6: @ Tampa Bay Buccaneers

The Niners will have 10 days to prepare for this game and this trip. Also, Brock Purdy is 2-0 against the Buccaneers, including a 23-20 nailbiter at Raymond James. The Niners will edge the Bucs out again, with Purdy leading them on a game-winning drive to set up the field goal.

WIN

Week 7: vs. Atlanta Falcons (Sunday Night Football)

The Falcons will still be a solid team, albeit with a quarterback controversy. Substantially, the Niners can pressure the quarterback, the defense will stuff Bijan Robinson. The Niners win this one in a thriller.

WIN

Week 8: @ Houston Texans...