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The Buffalo Bills 2025 NFL schedule is out, and we now know when and where Josh Allen and company will play on their quest to finally get over the hump and take the franchise back to the Super Bowl. With that in mind, let’s go through our Bills game-by-game predictions following the 2025 NFL schedule release.
Sun. Sept. 7, 8:20 p.m. NBC
The season opener is a rematch of arguably the best game of the 2024 NFL season as the Bills take on the Ravens in Buffalo. That said, it is also a runback of Buffalo’s worst 2024 beatdown, a 35-10 Week 4 drubbing.
Presumably, in early September, it won’t be snowing like it did in the playoffs (although in Western New York, you never know), which is a plus for Lamar Jackson and the Ravens. Plus, Baltimore will be out for revenge, while this is just game one of what Buffalo hopes is a 20 or 21-game season. That’s why the Ravens will take this one.
LOSS
Record: 0-1
Sun. Sept. 14,1 p.m. CBS
What’s the best way to get off the schneid and get your first win of the season? Play the Jets, of course!
The Bills will roll into MetLife Stadium with a bad taste in their mouth and take it out on the J-E-T-S. This one will be a laugher before the halftime show commences, and the Bills will end their losing record for the last time in 2025.
WIN
Record: 1-1
Thu. Sept. 18, 8:15 p.m. Prime Video
The AFC East is the gift that keeps on giving to the Bills. While the Patriots could be improving with a new coach and a young QB, the Jets are still the Jets, and the Dolphins may have gotten worse this offseason.
Buffalo hasn’t lost to Miami since Week 3 of the 2022 NFL season, and the ‘Phins won’t reverse that trend anytime soon, especially not on a Thursday night affair in Buffalo.
WIN
Record: 2-1
Sun. Sept. 28, 1 p.m. CBS
The Saints may be the worst team in the NFL this season, which means it may be Trubisky Time early in this Week 4 tilt.
WIN
Record: 3-1
Sun. Oct. 5, 8:20 p.m. NBC
The Patriots are the AFC team to watch this season for Bills Mafia as Mike Vrabel and Drake Maye will make this team much better than it’s been the last few seasons. That said, after years of Brady Beatdowns, Buffalo will want to make a statement that they are still the big dogs on the block, and Sunday Night Football is a good stage to do it on.
WIN
Record: 4-1
Mon. Oct. 13, 7:15 p.m. ESPN
The Falcons are a mess of a franchise, but Michael Penix Jr. may be good enough...
