ClutchPoints
With Week 6 of the 2025 NFL season approaching, fantasy football managers are navigating one of the most unpredictable positions in the game, which is wide receiver. Every week, a mix of emerging talents and established stars has reshaped the landscape. Players like Amon-Ra St. Brown, Drake London, Rome Odunze, and Ja’Marr Chase headline this week’s rankings. They offer both reliability and explosive upside.
Five weeks into the season, trends are beginning to stabilize. Wide receivers remain volatile from week to week. Patterns of usage, target share, and quarterback chemistry are starting to define the hierarchy, though. Week 5 reinforced that youth continues to lead the way. Emeka Egbuka topped all receivers with 31.3 fantasy points, followed closely by Ja’Marr Chase (29), Jaxon Smith-Njigba (27.2), and Puka Nacua (24.5). Veterans Stefon Diggs (24.6) and Deebo Samuel Sr. (23.6) also reminded fantasy football managers they’re not ready to surrender the spotlight.
However, Week 6 brings new challenges. With the Houston Texans and Minnesota Vikings on bye, fantasy lineups will miss heavyweights like Justin Jefferson and Nico Collins. That absence creates opportunities for others to step up. It will also forces managers to make tough choices among mid-tier options. Whether you’re chasing volume, big-play potential, or red-zone targets, knowing who to trust this week can make all the difference.
Here we will look at our NFL Fantasy Football Wide Receiver Rankings entering Week 6 of the 2025 regular season.
Few players have been as consistently dominant as Amon-Ra St. Brown. In Week 5, he caught eight of nine targets for 100 yards in Detroit’s 37–24 win over Cincinnati. He’s now topped 70 yards in four straight games and scored six touchdowns over that stretch. St. Brown remains Jared Goff’s top target and a focal point of one of the league’s most balanced offenses. Facing a struggling Kansas City defense, St. Brown is once again locked in as a top-three option this week.
Drake London finally had the breakout performance fantasy football managers were waiting for. Against Washington, he recorded 110 yards and his first touchdown of the year. London also doubled his previous season high for receiving yards. With Darnell Mooney sidelined due to a hamstring injury, London became the clear focal point in the Falcons’ passing attack. His combination of size and route precision makes him a matchup nightmare. Buffalo’s secondary has also allowed multiple 100-yard games this year. Expect London to maintain WR1 production moving forward.
Rome Odunze’s consistency has made him one of the league’s most dependable receivers. He extended his scoring streak to four straight games in Week 5. That brought his season touchdown total to five. Chicago’s passing game just runs through Odunze. He is proving to be nearly matchup-proof with his ability to win deep and over the middle. Washington’s secondary also ranks near the...
