NFL Week 6 brings some tough quarterback decisions. The good news? There are plenty of good matchups to exploit and some struggling defenses ready to be picked apart. The bad news? Key injuries have shaken things up. Here’s who to start and who to bench at quarterback this week.
Fantasy point totals are calculated by fantasydata.com.
The Buccaneers quarterback continues his red-hot 2025 campaign after an excellent Week 5 performance in the 38-35 shootout win over Seattle. The man has been on fire all season with 10 touchdowns against just one interception through five weeks. That kind of ball security is elite. He picked apart the Seahawks’ secondary and gets another favorable matchup this week against a messed-up 49ers defense.
San Francisco has allowed multiple passing touchdowns in four of their five games, and their defensive backfield is dealing with injuries. Mayfield has found chemistry with his receivers, especially with Emeka Egbuka, which was visible throughout the game, and he’s been money in the red zone all season. This one’s a no-brainer for anyone’s starting lineup.
Love gets a prime matchup at home against the Cincinnati Bengals’ defense that’s been getting tormented all season. Cincinnati just let Jake Browning throw for 251 yards and three touchdowns in Week 5, and most of that came late when the game was out of reach. Love comes in fresh after the bye with eight touchdowns and only one pick on the season.
The Bengals can’t get pressure on quarterbacks, and they’re giving up big plays left and right. The Green Bay Packers have plenty of weapons to attack Cincinnati’s weak secondary. The Packers are favored by double digits with a team total over 30 points. Everything lines up for Love to fire up this week.
Prescott is on fire right now after dropping four touchdowns in the Dallas Cowboys‘ 37-22 win over the New York Jets. He’s racked up 101.2 fantasy points through five weeks and proved he can put up big numbers even without CeeDee Lamb. That four-touchdown performance shows his ceiling is still sky-high. Carolina’s defense has been a fantasy goldmine for quarterbacks all season, ranking in the bottom third in pass defense and giving up big plays constantly.
The Carolina Panthers are facing issues putting pressure on the QB, so Prescott should have plenty of time in the pocket. Dallas needs this win to keep their playoff...