We are three full weeks into the 2025 NFL season, and with that, you are three weeks into your fantasy football season. Plenty of standout performances from key players, as well as goose eggs from highly-drafted players, has made this season tough to predict thus far.
The depth of your fantasy football roster is already being tested, as a plethora of quarterbacks have already missed time this season. All major offensive positions have been hit by injuries so far this season, as the quarterback (Joe Burrow), running back (James Conner), wide receiver (CeeDee Lamb), and tight end (George Kittle) spots have all had key players go down.
The following list includes players (except one) who are rostered on fewer than 50 percent of all ESPN rosters, making the chances you can pick them up pretty high. Heading into Week 4, try your best to button up the edges of your roster as you look to start the season strong.
1. RB Trey Benson, Arizona Cardinals
54.8% Rostered
Trey Benson kicks off our Week 4 waiver wire pickups, and he technically is breaking the only rule of this article, as he is rostered on more than 50 percent of ESPN teams. However, with James Conner going down for the rest of the season with a foot injury, Benson skyrockets up the RB rankings and becomes a league winner for you to target.
Even when Conner was healthy, Benson was still seeing work, so he has already been a valuable part of the Arizona Cardinals’ offense. Expecting Benson to slide into 100 percent of Conner’s workload right off the bat isn’t realistic, but expecting 15-plus touches from the former Florida State running back on a weekly basis is, presenting solid value for your fantasy football roster.
2. WR Elic Ayomanor, Tennessee Titans
21.1 Rostered
Rookie Elic Ayomanor was at the bottom of the Week 3 waiver wire pickups, but he has strung together two consecutive weeks with a touchdown, elevating him into the top wide receiver spot this week. While trusting members of the Tennessee Titans offense can be a tough pill to swallow, it is clear that the Calvin Ridley experiment is struggling to get off the ground, as rookie Cam Ward prefers Ayomanor.
Another week, another TD for Elic Ayomanor. You love to see it. pic.twitter.com/tafvYdb5hG
— Wyatt (@WyattB_FF) September 21, 2025
The Stanford rookie has caught a touchdown in back-to-back weeks and has been the lone bright spot in TEN’s passing attack, having earned at least five targets in each of his first three career games.
3. RB Bhayshul Tuten, Jacksonville Jaguars
48.1% Rostered
Another rookie, Bhayshul Tuten, finds himself in these Week 4 waiver wire pickups, as he has looked the part as the RB2 for the Jacksonville Jaguars. Playing second fiddle behind Travis Etienne, Tuten scored his second-career touchdown this past week, the first of his career on the ground, as he has now earned six-plus carries in...