Fantasy Football Running Back Rankings: Week 16 2025

Fantasy Football Running Back Rankings: Week 16 2025
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Week 16 is fantasy football’s pressure cooker. For many leagues, this is the championship round. For others, it’s the final hurdle before glory. At no position is the balance between volume, matchup, and game script more important than running back. Touches are king. However, efficiency and pass-game involvement often decide who delivers a league-winning performance and who leaves managers agonizing over ‘what ifs.’

With no bye weeks remaining, fantasy football managers technically have access to every back in the league. Still, injuries, role volatility, and matchup quirks make the decision-making process more complex than ever.

Below is a breakdown of the running backs you can trust as foundational plays in Week 16, followed by sleeper options capable of swinging championship matchups if deployed correctly.

Week 16 Top Fantasy Football Picks – 2025

De’Von Achane, MIA (vs. CIN)

De’Von Achane reasserted himself as the focal point of Miami’s offense in Monday night’s loss to Pittsburgh. He piled up 127 scrimmage yards while leading the team in both rushing and receiving. Coming off a rib injury in Week 14, Achane looked fully healthy. He carried the ball 12 times for 60 yards and hauled in all six of his targets for 67 yards.

What stood out most was his involvement in the passing game. That neutralized concerns about negative game script. When Miami fell behind, Achane became even more valuable. That versatility makes him one of the safest fantasy football options on the board. Against a Bengals defense that has struggled to contain backs in space, Achane profiles as an elite RB1.

Bijan Robinson, ATL (@ ARI)

Bijan Robinson delivered one of his most complete performances of the season in Thursday night’s win over Tampa Bay. He rushed 19 times for 93 yards and a touchdown while adding eight receptions for 82 yards on 11 targets. The result was 175 total yards and a dominant showing in all phases of the offense.

Atlanta leaned heavily on Robinson both between the tackles and as a receiver.. His usage in the passing game continues to elevate his weekly floor, especially in PPR formats. With Arizona struggling to consistently limit explosive running back performances, Robinson enters Week 16 as a locked-in top-five option. He is a potential league-winner if the Falcons continue to feed him at this rate.

Christian McCaffrey, SF (@ IND)

Christian McCaffrey battled through a back issue in Week 15. He still delivered, though, carrying the ball 22 times for 73 yards and a touchdown. Sure, his receiving role was quieter than usual with just one catch for 14 yards. However, McCaffrey extended his touchdown streak to four straight games with a one-yard plunge in the second quarter.

Even at less than 100 percent, McCaffrey remains one of the safest fantasy plays in football due to his red-zone role and workload security. Indianapolis presents a favorable matchup. That’s particularly true if San Francisco controls the tempo. Expect McCaffrey to reclaim a larger share of passing-game work in Week...