Fantasy Football Running Back Rankings: Week 10

Fantasy Football Running Back Rankings: Week 10
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Every fantasy football season reaches a turning point. For 2025, Week 10 feels like that moment. Running back committees are shifting, injuries are stacking up, and previously overlooked players are rising to fantasy football prominence. Whether you’re clinging to playoff hopes or cruising atop the standings, getting your running back lineup right this week could define the rest of your season.

Key insights

As we dive into Week 10, remember that the Cowboys, Bengals, Titans, and Chiefs are on their byes. That takes some heavy hitters like Tony Pollard, Javonte Williams, and Isiah Pacheco off the board. On the flip side, fantasy football managers regain key contributors from the Buccaneers, Browns, Jets, and Eagles. This gives some rosters much-needed reinforcements.

Recall that Week 9 gave us fireworks. Christian McCaffrey reasserted his dominance, and Rico Dowdle exploded. Meanwhile, Kyle Monangai emerged as a legit flex option. That said, Week 10 brings new matchups and tougher choices.

Here we will look at our NFL Fantasy Football Running Back Rankings entering Week 10 of the 2025 regular season.

Week 10 Top Fantasy Football Picks – 2025

Josh Jacobs, GB (vs. PHI)

Josh Jacobs continues to prove that consistency is king. Against Carolina in Week 9, Jacobs carried the ball 17 times for 87 yards and a touchdown. He also added four receptions for 13 yards. Though Green Bay fell short, Jacobs once again delivered as a fantasy football workhorse.

Jacobs’s 10 rushing touchdowns through eight weeks rank among the league’s best. His red-zone volume is also unmatched. He is averaging nearly five touches inside the 20 per game. The Eagles have also quietly allowed multiple running backs to post strong fantasy outings due to their soft coverage against receiving backs. Jacobs’ dual-threat ability keeps him in elite RB1 territory for Week 10’s Monday night showdown.

Bijan Robinson, ATL (vs. IND)

Even when the Falcons struggle, Bijan Robinson finds ways to produce. In last week’s narrow loss to New England, Robinson totaled 96 scrimmage yards on 22 touches. This included a career-high 10 targets. Sure, his rushing numbers were modest at 46 yards on 12 carries. However, his PPR value soared thanks to his heavy involvement in the passing game.

Facing the Colts, Robinson gets a prime opportunity to bounce back in a game where Atlanta should control the pace. Indianapolis ranks 28th in receptions allowed to running backs. As such, expect Robinson to remain the focal point. He’s a top-five fantasy football play with a massive ceiling if he finds the end zone.

James Cook, BUF (@ MIA)

James Cook finally looked like the every-down threat Buffalo envisioned in Week 9. He logged 27 carries for 114 yards and added one catch for 11 yards against Kansas City. That usage spike is exactly what fantasy football managers wanted to see.

Miami’s defense presents a balanced challenge. They are top-10 in yards allowed per carry, but bottom-five in receptions allowed to running backs. Cook’s explosiveness in open space makes...