Cameras Caught Patrick Mahomes’ Heartbreaking Reaction After Suffering Serious Knee Injury vs. Chargers [VIDEO]

Cameras caught Patrick Mahomes’ devastated reaction after leaving Sunday’s game against the Los Angeles Chargers with a gruesome-looking knee injury.

On the Kansas City Chiefs’ final drive of their must-win game, Patrick Mahomes suffered a knee injury after getting tackled by Da’Shawn Hand. Mahomes was down for several minutes and did not return.

This play might be the last time we see Patrick Mahomes on the field this season. pic.twitter.com/tYj9iB9Xvb

— Jason Krump (@JasonKrump) December 14, 2025

To add salt to injury? Backup quarterback Gardner Minshew II threw a game-sealing interception with a chance to win. The Chiefs fell to 6-8 and have officially been eliminated from playoff contention.

After the game, cameras showed Patrick Mahomes visibly distraught with a towel over his head as he was helped by trainers:

Chiefs Patrick Mahomes with a towel over his head as he is helped to the locker room after suffering a knee injury late in the 4th quarter. pic.twitter.com/povW0Gi6Iw

— Ryan Blank (@rmblank4) December 14, 2025

Mahomes was having a sluggish outing before the injury. Per ESPN, the 30-year-old finished with just 189 passing yards on 16 completions for no touchdowns and one back-breaking interception.

The Chiefs had played in seven straight AFC Championship Games to begin Mahomes’ career. They won five of them and claimed three Super Bowl championships in that period.

But for the first time since 2014, the Chiefs will be watching the playoffs from home.