Buffalo Bills vs. New York Jets NFL Week 18 odds, spread, betting info

Before embarking with a road warrior mentality during this season’s playoffs, the Buffalo Bills must first get through their final regular-season game of the 2025 NFL season. They’ll welcome the New York Jets for what could be the final game in the original Highmark Stadium, with its successor set to open across the road for the 2026 NFL season.

Odds for Bills vs. Jets in NFL Week 18

It’s a game that doesn’t hold much in the way of high-stakes intrigue, with the Jets firmly out of playoff contention and Buffalo is only likely to move up one notch to the six seed with a win and the right combination of losses elsewhere in Week 18. Entering Sunday’s game at Highmark, FanDuel Sportsbook initially listed the Bills as 11.5-point favorites (-11.5) over the woebegone Jets, with an over/under set at O/U 39.5.

But that was before Week 17 was fully in the books, and now odds look a little bit different a day later. The current odds for Bills-Jets with FanDuel Sportsbook now lists the Bills as 7.5-point (-7.5) home favorites over the Jets in Week 18, with an over/under set at O/U 38.5.

These are two teams heading in very different directions, perhaps even beyond the immediate playoff picture. The Jets never managed to get much going under first-year head coach Aaron Glenn, and there are some who wonder how long he has left at the helm. The Bills will probably prioritize resting key starters in Week 18, which could give this matchup the same sort of air surrounding a preseason game — and that’s probably what has the odds shifting so much this early.

The Bills lead the overall series with the Jets 72-58-0. Buffalo has won the last four matchups, and 11-4 with Josh Allen at quarterback since 2018. These teams last met in mid September, with the Bills winning a 30-10 game in the Meadowlands.

Buffalo will host the Jets at Highmark Stadium on Sunday, January 4 2026 for a 4:25 p.m. EST game in what could end up being the final game at “The Ralph” in Orchard Park, NY. Interestingly, the Bills’ first opponent to open the first regular season in then Rich Stadium (1973) was the Jets.