Buffalo Bills schedule predictions: Game by game Bills predictions 2025

Buffalo Bills schedule predictions: Game by game Bills predictions 2025
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The Buffalo Bills delivered their fifth consecutive season with 11-plus wins last year, finishing with a 13-4 record. They reached the AFC Championship Game for the second time in five years, with Josh Allen winning NFL MVP. After falling just short of the Super Bowl, Buffalo will have a chip on its shoulder.

The Bills have consistently proven to be one of the best teams in the NFL, often overcoming injuries in the process. Even with a tough schedule ahead, they are Super Bowl contenders once again this season.

Let’s dive into our game-by-game Bills predictions for the regular season.

Week 1 vs Baltimore Ravens: Loss (0-1)

There will be fewer better NFL games in 2025 than the Bills versus the Baltimore Ravens. The perennial MVP favorites, Allen and Lamar Jackson, put up a great heavyweight fight nearly every time these two teams match up. Buffalo does have the home-field advantage, but the improvements made to the Ravens’ secondary this offseason could give them an edge. Baltimore pulls it out late, but it’ll be a much better game than the 35-10 blowout from the 2024 season.

  • Prediction: Baltimore Ravens 28, Buffalo Bills 24

Related: 1 Bold Training Camp Prediction for Each AFC Team, Including the Bills

Week 2 @ New York Jets: Win (1-1)

Sometimes, intradivisional matchups can be closer than many expect. There’s not a lot of reason to expect that in Buffalo’s Week 2 road matchup against the New York Jets. Not only are the Jets integrating new schemes on both sides of the ball, but they have a quarterback in Justin Fields who really struggles when pressured. The Bills take care of business in three quarters, cruising to their first win of the season.

  • Prediction: Buffalo Bills 34, New York Jets 20

Week 3 vs Miami Dolphins: Win (2-1)

The Bills’ schedule in 2025 opens relatively season after the season-opener versus the Ravens. While Buffalo might not find it as easy to pressure Tua Tagovailoa as it used to be, given the improvements made to the Miami Dolphins‘ offense live, it won’t matter because of the other side of the ball. Allen and the Bills’ receiving corps should have a field day in Week 3.

  • Prediction: Buffalo Bills 31, Miami Dolphins 24

Related: NFL power rankings 2025, see where the Bills land

Week 4 vs New Orleans Saints: Win (3-1)

It’s going to be another victory for the Bills, this time led by the defense. Likely facing rookie quarterback Tyler Shough, Buffalo’s front seven will cause all kinds of problems for the first-year signal-caller. The pressure results in a pair of interceptions, both of which the Bills’ offense turns into scoring drives. Buffalo cruises to a 3-1 start.

  • Prediction: Buffalo Bills 35, New Orleans Saints 20

Week 5 vs New England Patriots: Win (4-1)

Momentum keeps building in Buffalo as the team quickly starts creating some distance in the AFC. The New England Patriots made substantial improvements on...