Dawgs By Nature
Cleveland plays Buffalo in Week 16 of the 2025 NFL season
The Cleveland Browns will face the Buffalo Bills in Week 16 of the 2025 NFL season.
The Bills are coming off an incredibly successful season in which they were only a couple of possessions away from winning the conference championship over Patrick Mahomes and the Chiefs. It’s no secret that Mahomes has been the bane of this Sean McDermott-led Buffalo team, and they'll be looking to get revenge in the 2025/2026 season.
Cleveland has performed fairly well against Buffalo throughout their past two matchups, winning one and losing the other by only one possession.
With the 2025 NFL schedule now released, we can break down each matchup and each team for this season.
Here is a quick primer on the match-up between the Browns and Bills.
Opponent: Buffalo Bills
Date: December 21, 2025
2024 record: 13-4, first place in the AFC East
Last playoff appearance: Lost to the Kansas City Chiefs, 32-29, in the 2024 AFC Championship
Browns all-time record vs. Bills: 13-10
Browns record on the road vs. Bills: 5-6
First meeting: Browns won, 27-10, on November 26, 1972
Most recent meeting: Bills won, 31-23, on November 20, 2022
Buffalo’s 2025 Draft Class: Maxwell Hairston (CB), T.J. Sanders (DT), Landon Jackson (DE), Deone Walker (DT), Jordan Hancock (S), Jackson Hawes (TE), Dorian Strong (CB), Chase Lundt (OT), Kaden Prather (WR)
Free agents lost/not-resigned via Over The Cap: Kaiir Elam (CB), Sam Martin (P), Mack Hollins (WR), Amari Cooper (WR), Von Miller (DE), Rasul Douglas (CB), Austin Johnson (DT), Dawuane Smoot (DT), Quinton Jefferson (DT), Jordan Phillips (DT), Quintin Morris (TE)
Free agents signed/retained via Over the Cap: Darrynton Evans (RB), Josh Allen (QB), Matt Milano (LB), Greg Rousseau (DE), Reggie Gilliam (FB), Ty Johnson (RB), Terrel Bernard (LB), Reid Ferguson (LS), Shane Buechele (QB), Khalil Shakir (WR), Christian Benford (CB), Damar Hamlin (S), Ryan Van De Mark (OT), Alec Anderson (OT), Elijah Moore (WR), Joey Bosa (DE), Josh Palmer (WR), Darrick Forest (S), Dane Jackson (CB), Michael Hoecht (DE), Tre’Davious White (CB), Larry Ogunjobi (DT), Kendrick Green (OG)
