Broncos vs. Jaguars predictions: Final score picks for NFL Week 16

Broncos vs. Jaguars predictions: Final score picks for NFL Week 16
Mile High Report Mile High Report

The Denver Broncos go into Week 16 looking to defend their 11-game win streak and undefeated home record against the red-hot Jacksonville Jaguars. Coming off a big win over the Green Bay Packers who had come into Denver as favorites despite having a worse record, confidence should be running sky high for this Broncos football team.

There is a scenario where the Broncos can clinch all of the things from the number one seed in the AFC and the AFC West division title. It’s unlikely for all of those to happen, but they can certainly take the division with the win and a Los Angeles Chargers loss on Sunday.

Game Overview

Denver Broncos vs. Jacksonville Jaguars
Sunday, December 21, 2025 at 2:05 P.M. Mile High time
Empower Field at Mile High in Denver, Colorado
ATS Betting Lines: Denver -3.5
Moneyline Odds: Denver -180 / Jacksonville +152
Over/Under: 46.5
Note: All odds courtesy of FanDuel Sportsbook.

Broncos vs Jaguars Score Predictions

Collectively, our Mile High Report staff is predicting a Broncos 31-16 win at home over the Jaguars. Here’s how each of us predicted things would go individually:

Broncos 27, Jaguars 17

Part of me doesn’t want to stop predicting one-score games, but this is a matchup that I feel favors the Broncos in almost every category. Trevor Lawrence has been playing out of his mind, but his worst games have all come against elite defenses. With Bo Nix playing like the best version of himself, I feel like the Broncos will pull away from the Jags in this game at some point. – Tim Lynch

Broncos 31, Jaguars 23

The tests don’t stop for the Broncos. The Jags come in on a heater with 5 wins in a row. They have a strong run game and a quarterback who is on fire. Their defense is exceptionally great at taking the ball away. That being said, they haven’t played a team at the Broncos level yet. I like Denver at home with the altitude and the rabid fans behind them. – Sadaraine

Broncos 41, Jaguars 17

Broncos haven’t lost at home since Week 6 of 2024, they’ve won 11 straight games, and QB Bo Nix is coming off his best career game. Last week, this team just defeated a tough Packers team that came into Mile High hot and feeling good and will do the same against the Jags this Sunday.

The Jags have beat up on the Titans, Jets, and a Colts team after they lost their QB in recent weeks. The Broncos are a different animal and are peaking at the right time.

Bo Nix has back-to-back 4 TD performances(If Geno Smith can do it against the Jags, Bo can), RJ Harvey tops 100 yards from scrimmage, the defense gets multiple turnovers and 5+ sacks of Trevor Lawrence and clinch the AFC West after the Chargers fall to the Cowboys. – Scotty Payne

Broncos 27, Jaguars 20

Two division leaders are going head-to-head...