Mile High Report
The Denver Broncos begin a streak of four out of five games on the road in Week 2. Every win in this stretch is going to be hugely important to them down the road and the Indianapolis Colts are a beatable team if Denver can play a sound football game on both sides of the ball. The line is tight in this game, so bettors think this is going to be a flip of the coin.
Denver Broncos at Indianapolis Colts
Sunday, September 14, 2025 at 2:05 P.M. Mile High time
Lucas Oil Stadium in Indianapolis, Indiana
ATS Betting Lines: Denver -2.5
Moneyline Odds: Denver -122 / Kansas City +104
Over/Under: 43.5
Note: All odds courtesy of FanDuel Sportsbook.
Collectively, our Mile High Report staff is predicting a Broncos 28-13 road win over the Colts in Week 2. We all predicted wins, but here is where we each landed individually on the score:
The defense finally gives up a touchdown, but only field goals after that. Meanwhile, the Broncos offense finds some groove in this game and grinds out their first road win of the season. They need this 2-0 start, so they better go get it! – Tim Lynch
The Broncos will have to improve on the offensive side of the ball if they want to take care of business on the road in Indianapolis. With a banged-up secondary, I expect Nix to be able to be fairly effective moving the ball through the air. However, a consistent running game would go a long way toward securing a victory. On defense, they need to contain Jonathan Taylor who scampered for over 100 yards against them last season and force Daniel Jones into some bad decisions. I expect this game to be close, but with Denver moving to 2-0 on the season. – Chris Hart
Week one might have exposed some of the offensive flaws for the Broncos, but we saw a defense that has the potential to win games all on its own. The Colts looked like they were playing the Little Sisters of the Poor School for the Blind, so we learned nothing about them. By all accounts, Denver is likely the better team. They will clean things up on offense and the defense will look as good as they always do. – Adam Malnati
I know for a fact that Daniel Jones will not light up the Denver defense like he did the Dolphins, so there’s one loose end already tied up. I also know this Colts defense doesn’t have what it takes to slow down the Dobbins and Harvey hype train. The offense is going to pick things up this week, moving on from the Titans, and the defense might just get even better. This shouldn’t be as close as last year was. – Ross Allen
The Colts...
![HC Sean Payton on Week 2 practices: ‘[I] thought we’ve had real good preparation’](https://i.ytimg.com/vi/uQAmcpxaYR0/mqdefault.jpg)
