Mile High Report
It’s amazing how a one-point loss on the road against a perceived inferior team can throw an entire season on its head. That’s kind of what happened with the Denver Broncos on Sunday, because now they have to try to take down the red-hot Los Angeles Chargers on the road in Week 3. Lose here and they are instantly two games back from the AFC West division lead. That’s the beginning of a long climb if it happens. It’s already a must-win situation for Denver.
Denver Broncos at Los Angles Chargers
Sunday, September 21, 2025 at 2:05 P.M. Mile High time
SoFi Stadium in Los Angeles, California
ATS Betting Lines: Los Angeles -3
Moneyline Odds: Denver +130 / Los Angeles -154
Over/Under: 45.5
Note: All odds courtesy of FanDuel Sportsbook.
Collectively, our Mile High Report staff is predicting a Broncos 22-21 road win over the Chargers in Week 3. The score prediction shows it was a mixed bag of results, so here is where we each landed individually on the score:
Until the Broncos prove they can win close games against playoff-caliber opponents, I’m no longer going to sip the Kool-Aid. They are 2-7 against teams in one-score games since the start of 2024 and two of those losses came against these very same Chargers. Their only wins against the hapless New York Jets and Tennessee Titans. They have got to figure this our or they’ll be a fringe .500 football team. – Tim Lynch
It’s only the third week of the season, but the Broncos and Chargers matchup on Sunday will be an important game for both. The Chargers are 2-0 and the Broncos are 1-1. The winner of this game will have an early lead in the AFC West. In order for the Broncos to win, they will have to play mistake free football on offense and limit Justin Herbert and their passing attack. That’s a tough ask on the road, and I’m not sure Denver can get the job done in Los Angeles. – Chris Hart
Last week’s game has obviously let doubt set in about how good this Broncos defense can be. But I’m sure there’s something they can figure out to get things going back in the right direction. And the offense saw a big boost to production, and the run game is looking as good as it has ever looked over the last decade. I’m optimistic about this week, and no Khalil Mack makes a big difference. – Ross Allen
As much as I respect Jim Harbaugh, I will never stop calling our away games at the Chargers our extra home game of the season. Broncos fans will be out in droves. Herbert will wilt under pressure per usual and the Broncos tie things up atop the AFC West. – Sadaraine
When a Week 3 game...
