Broncos vs. Bengals predictions: Final score picks for NFL Week 4

Coming off back-to-back brutal road losses, the Denver Broncos will be looking to ‘get right’ at home against the Cincinnati Bengals on Monday Night Football. While this game had the makings of a great Bo Nix vs. Joe Burrow rematch to last year’s exciting contest, it will not happen with Burrow now out for the year. This is now a game the 1-2 Broncos must have if they hope to get their season back on track.

Game Overview

Cincinnati Bengals at Denver Broncos
Monday, September 29, 2025 at 6:15 P.M. Mile High time
Empower Field at Mile High in Denver, Colorado
ATS Betting Lines: Denver -7.5
Moneyline Odds: Denver -460 / Cincinnati +360
Over/Under: 43.5
Note: All odds courtesy of FanDuel Sportsbook.

Collectively, our Mile High Report staff is predicting a Broncos 34-14 prime time home win over the Bengals in Week 4. The score prediction shows us all predicting double-digit wins, so here is where we each landed individually on the score:

Broncos 27, Bengals 16

I don’t see any reason why the Broncos shouldn’t win by two scores in this game. If they don’t, I’ll be a bit troubled even if they do win this game. They do seem to play up or down to their competition each week and that is not the hallmark of a contender. With no Joe Burrow, the Broncos should dominate from start to finish. However, given how they have started the season, I do see potential for them to continue struggling against inferior opponents. – Tim Lynch

Broncos 34, Bengals 13

After dropping back-to-back heartbreakers by a point against the Colts and Chargers, the Broncos enter their Monday Night Football matchup against the Bengals with their backs up against the wall. They need a statement victory to give the team a much-needed boost of confidence moving forward. I believe they will deliver at home and secure a decisive victory against a Bengals team that just had 48 points dropped on them by the Minnesota Vikings. – Chris Hart

Broncos 31, Bengals 10

Imagine giving the Chargers a chance to run away with the division before we even reach the quarter pole of the season. That’s the scenario that Denver finds themselves in after failing to finish for the second week in a row. That can’t happen against a Bengals team that is missing their leader. With Joe Burrow sidelined, expect the defense to lock up the Bengals. That should give Bo Nix the opportunity to get the offense on track. – Adam Malnati

Broncos 38, Bengals 13

After two tough road losses, Denver is in need of a “get right” game. The offense needs to put drives together that end in touchdowns and the defense needs shut an opponent down. Beyond all of that, the Broncos need to play a clean game and leave no doubt. Denver must build some confidence for the rest of the season and play a complete game against a hobbled opponent at...